肝胆胰外科杂志 ›› 2021, Vol. 33 ›› Issue (5): 280-284.doi: 10.11952/j.issn.1007-1954.2021.05.005

• 论著 临床研究 • 上一篇    下一篇

儿童胆道扩张症与胰胆管合流异常的相关性

刘璐,张廷冲,陈巍

  

  1. 国家儿童医学中心(北京)/首都医科大学附属北京儿童医院 普外科,北京 100045
  • 收稿日期:2020-11-03 出版日期:2021-05-15 发布日期:2021-06-07
  • 通讯作者: 张廷冲,主任医师,博士,E-mail:ztc@bch.com.cn。
  • 作者简介:刘璐(1985-),男,北京人,主治医师,硕士。

Correlation of biliary dilatation and pancreatiobiliary maljunction in children

LIU Lu, ZHANG  Ting-chong, CHEN Wei   

  1. National Medical Center for Children’s Health/Department of General Surgery, Beijing Children’s Hospital, Capital Medical University, Beijing 100045, China
  • Received:2020-11-03 Online:2021-05-15 Published:2021-06-07

摘要:

目的 通过回顾性分析先天性胆道扩张症(CBD)临床病例资料,比较合并胰胆管合流异常(PBM)与无合流异常病例的临床特征之间的差异,探讨PBM以及共同管长度与CBD的发病、临床症状、相关实验室检查结果的相关性,为CBD的发病机理和诊断治疗提供新的理论依据。方法 回顾性总结2017年1月至2019年12月首都医科大学附属北京儿童医院普外科收治的胆道扩张症病例临床资料,83例胆道扩张症患儿纳入研究,以MRCP中胰胆管共同管长度为分组标准,分为合流异常组(共同管长度≥5 mm,n=47)与非合流异常组(共同管长度<5 mm,n=36),研究指标包括发病年龄、性别、临床症状、相关实验室检查、共同管长度、胆道结石以及胆总管囊肿大小,研究结果采用非参数检验和χ2 检验。结果 在临床症状中,发热、黄疸、白色大便及胆道结石两组间无统计学差异(P>0.05),腹痛症状合流异常组多于无合流组(P<0.05);实验室检查结果AST、ALT、TBIL、DBIL及IBIL两组间无统计学差异(P>0.05),血清淀粉酶检测合流异常组高于无合流异常组(P<0.05);合流异常组胆总管呈囊肿型32例(38.6%),梭型15例(18.1%),无合流异常组胆总管呈囊肿型26例(31.3%),梭型10例(12.0%),两组间无统计学差异(P>0.05),但胆总管囊肿体积合流异常组小于无合流异常组(P=0.02)。结论 先天性胆道扩张症合并胰胆管合流异常的患儿出现腹痛症状较早、较严重,同时血清淀粉酶较高,合并胰腺炎较常见,故易于做出早期诊断,可能也是本组胆总管囊肿体积较小的原因。本研究胰胆管共同管长短与先天性胆道扩张症的临床症状、肝功能、胆红素及血清淀粉酶等水平无明确相关性,故不能单纯以胰胆管共同管长度判断病情轻重。

关键词:

Abstract:

Objective To put forward new theoretical basis for pathogenic mechanism, diagnosis and treatment of congenital biliary dilatation (CBD) by retrospective clinical study comparing the differences between pancreatiobiliary maljunction (PBM) cases and non-PBM cases, in which the correlation of CBD and PBM was investigated in terms of symptoms, sign, lab test results and the lengths of common channel. Methods Clinical data of CBD patients admitted in Department of General Surgery, Beijing Children’s Hospital from Jan. 2017 to Dec. 2019 were retrospectively analyzed. The enrolled 83 CBD patients were divided into two groups (PBM group, with length of common channel ≥5 mm, n=47; non-PBM group with length of common channel < 5 mm, n=36) according to the MRCP results. The research data included age of ailment, gender, symptoms, liver functions, BIL, AMY, common channel length, pancreatic stone and size of congenital choledochal cyst. Nonparametric test and χ2 -test were used for statistical analysis. Results Clinical studies showed that there were no significant differences between the two groups in terms of fever, jaundice, white stool or bile duct stones (P>0.05), while abdominal pain was prevalent in PBM group (P<0.05); lab results showed no significant differences in AST, ALT, TBIL, DBIL or IBIL between two groups (P>0.05), only AMY in PBM group appeared to be higher (P<0.05). The PBM group showed 32 cases (38.6%) of choledochal cyst and 15 cases (18.1%) of shuttle shape, while the non-PBM group showed 26 cases (31.3%) of choledochal cyst and 10 cases (12.0%) of shuttle shape, with no significant difference between two groups (P>0.05). However, the size of choledochal cyst appeared to be significantly smaller in the PBM group (P=0.02). Conclusion This research reveals that CBD associated with PBM will lead to early severe abdominal pain and higher AMY, which is easily to be diagnosed at an early stage, accounting for the smaller size of the cyst in PBM. The length of common channel shows no significant correlation with clinical test on liver functions, BIL, or AMY levels in CBD. Therefore, the length of common channel alone might not be used for judging the severity of CBD.

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中图分类号: 

  • ? R657.4+ 2
[1] 刘飞, 刘波, 祁春春, 马跃峰, 杨玉龙. 内镜逆行胰胆管造影诊治高龄高危IPMN[J]. 肝胆胰外科杂志, 2019, 31(8): 496-503.
[2] 王逢春,丛嘉. 胆囊腺瘤伴出血一例[J]. 肝胆胰外科杂志, 2013, 25(1): 80-80.
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